STEM CELL-DERIVED CARDIOMYOCYTES EXPRESSING A DOMINANT NEGATIVE PACEMAKER HCN4 CHANNEL DO NOT REDUCE THE RISK OF GRAFT-RELATED ARRHYTHMIAS

Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) beefeaters triple flavor twists show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.Our group

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